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HMGA2 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant HMGA2.

     
  • IF - HMGA2 Antibody (monoclonal) (M01) AT2383a
    Immunofluorescence of monoclonal antibody to HMGA2 on HeLa cell . [antibody concentration 10 ug/ml]
    detail
  • WB - HMGA2 Antibody (monoclonal) (M01) AT2383a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.86 KDa) .
    detail
  • E - HMGA2 Antibody (monoclonal) (M01) AT2383a
    Detection limit for recombinant GST tagged HMGA2 is approximately 0.1ng/ml as a capture antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession P52926
Other Accession NM_003483
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2D10
Calculated MW 11832 Da
Additional Information
Gene ID 8091
Other Names High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC
Target/Specificity HMGA2 (NP_003474, 1 a.a. ~ 92 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsHMGA2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. Liu Y, et al. Carcinogenesis, 2010 Jul 7. PMID 20610542.HMGA2 is a sensitive but not specific immunohistochemical marker of vulvovaginal aggressive angiomyxoma. McCluggage WG, et al. Am J Surg Pathol, 2010 Jul. PMID 20551826.HMGA2 and the p19Arf-TP53-CDKN1A axis: a delicate balance in the growth of uterine leiomyomas. Markowski DN, et al. Genes Chromosomes Cancer, 2010 Aug. PMID 20544840.HMGA1 and HMGA2 rearrangements in mass-forming endometriosis. Medeiros F, et al. Genes Chromosomes Cancer, 2010 Jul. PMID 20461755.

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$ 350.00
Cat# AT2383a
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Availability: 7-10 days
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