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HOXA11 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant HOXA11.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P31270 |
| Other Accession | NM_005523 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 5A3 |
| Calculated MW | 34486 Da |
| Gene ID | 3207 |
|---|---|
| Other Names | Homeobox protein Hox-A11, Homeobox protein Hox-1I, HOXA11, HOX1I |
| Target/Specificity | HOXA11 (NP_005514, 60 a.a. ~ 166 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HOXA11 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.
References
HOX A10 and HOX A11 mutation scan in congenital malformations of the female genital tract. Liatsikos SA, et al. Reprod Biomed Online, 2010 Jul. PMID 20457539.Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. Ester AR, et al. Am J Med Genet A, 2009 Dec. PMID 19938081.HoxA-11 and FOXO1A cooperate to regulate decidual prolactin expression: towards inferring the core transcriptional regulators of decidual genes. Lynch VJ, et al. PLoS One, 2009 Sep 3. PMID 19727442.DNA methylation analysis in liquid-based cytology for cervical cancer screening. Apostolidou S, et al. Int J Cancer, 2009 Dec 15. PMID 19609949.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.
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