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HOXB7 Antibody (monoclonal) (M04)

Mouse monoclonal antibody raised against a partial recombinant HOXB7.

     
  • WB - HOXB7 Antibody (monoclonal) (M04) AT2411a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (33 KDa) .
    detail
  • WB - HOXB7 Antibody (monoclonal) (M04) AT2411a
    Western Blot analysis of HOXB7 expression in transfected 293T cell line by HOXB7 monoclonal antibody (M04), clone 5B2.

    Lane 1: HOXB7 transfected lysate(24 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • WB - HOXB7 Antibody (monoclonal) (M04) AT2411a
    Western blot analysis of HOXB7 over-expressed 293 cell line, cotransfected with HOXB7 Validated Chimera RNAi ( (Cat # AT2411a )
    detail
  • E - HOXB7 Antibody (monoclonal) (M04) AT2411a
    Detection limit for recombinant GST tagged HOXB7 is approximately 0.1ng/ml as a capture antibody.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P09629
Other Accession NM_004502
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 5B2
Calculated MW 24015 Da
Additional Information
Gene ID 3217
Other Names Homeobox protein Hox-B7, Homeobox protein HHOC1, Homeobox protein Hox-2C, HOXB7, HOX2C
Target/Specificity HOXB7 (NP_004493, 55 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsHOXB7 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)
citation

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Background

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.

References

Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. De Souza Setubal Destro MF, et al. Int J Oncol, 2010 Jan. PMID 19956843.Differential expression of HOXB7 gene in multiple myeloma and extramedullary multiple myeloma patients. Novak EM, et al. Eur J Haematol, 2010 Feb 1. PMID 19878270.Inhibition of 13-cis retinoic acid-induced gene expression of homeobox B7 by thalidomide. Milanovi? D, et al. Int J Cancer, 2007 Sep 15. PMID 17514648.A role for the HOXB7 homeodomain protein in DNA repair. Rubin E, et al. Cancer Res, 2007 Feb 15. PMID 17308091.Correlation between genetic variations in Hox clusters and Hirschsprung's disease. Garcia-Barcel? MM, et al. Ann Hum Genet, 2007 Jul. PMID 17274802.

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$ 350.00
Cat# AT2411a
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Availability: 7-10 days
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