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IKBKG Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant IKBKG.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q9Y6K9 |
| Other Accession | BC050612 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4G9 |
| Calculated MW | 48198 Da |
| Gene ID | 8517 |
|---|---|
| Other Names | NF-kappa-B essential modulator, NEMO, FIP-3, IkB kinase-associated protein 1, IKKAP1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier, IKBKG, FIP3, NEMO |
| Target/Specificity | IKBKG (AAH50612, 1 a.a. ~ 419 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | IKBKG Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
References
Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. Mooster JL, et al. J Allergy Clin Immunol, 2010 Jul. PMID 20542322.NEMO gene mutations in Chinese patients with incontinentia pigmenti. Hsiao PF, et al. J Formos Med Assoc, 2010 Mar. PMID 20434027.The LCR at the IKBKG locus is prone to recombine. Fusco F, et al. Am J Hum Genet, 2010 Apr 9. PMID 20380930.IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth. Ammirante M, et al. Proc Natl Acad Sci U S A, 2010 Apr 20. PMID 20368414.Activation of noncanonical NF-kappaB signaling by the oncoprotein Tio. de Jong SJ, et al. J Biol Chem, 2010 May 28. PMID 20353939.
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