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JUP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant JUP.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | P14923 |
| Other Accession | BC011865 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2G9 |
| Calculated MW | 81745 Da |
| Gene ID | 3728 |
|---|---|
| Other Names | Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3 |
| Target/Specificity | JUP (AAH11865.1, 1 a.a. ~ 745 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | JUP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
References
Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma. Pryczynicz A, et al. Folia Histochem Cytobiol, 2010 Jan 1. PMID 20529828. The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis. Czyzewska J, et al. Folia Histochem Cytobiol, 2010 Jan 1. PMID 20529814. Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice. Fressart V, et al. Europace, 2010 Jun. PMID 20400443. Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children. Cabral RM, et al. J Invest Dermatol, 2010 Jun. PMID 20130592. Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1. Aktary Z, et al. Oncogene, 2010 Apr 8. PMID 20101217.
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