KHDRBS1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant KHDRBS1.
|Application ||WB, IHC, IF, E|
|Calculated MW||48227 Da|
|Other Names||KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, Sam68, p21 Ras GTPase-activating protein-associated p62, p68, KHDRBS1 (HGNC:18116)|
|Target/Specificity||KHDRBS1 (AAH00717, 176 a.a. ~ 275 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KHDRBS1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. Pedrotti S, et al. EMBO J, 2010 Apr 7. PMID 20186123.Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients. Sellier C, et al. EMBO J, 2010 Apr 7. PMID 20186122.Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Paronetto MP, et al. Cancer Res, 2010 Jan 1. PMID 20028857.Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies. Rajan P, et al. BMC Cell Biol, 2009 Nov 13. PMID 19912651.Expression and cytoplasmic localization of SAM68 is a significant and independent prognostic marker for renal cell carcinoma. Zhang Z, et al. Cancer Epidemiol Biomarkers Prev, 2009 Oct. PMID 19755649.
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