KLF1 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant KLF1.
|Application ||WB, IF, E|
|Calculated MW||38221 Da|
|Other Names||Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF|
|Target/Specificity||KLF1 (NP_006554, 183 a.a. ~ 237 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KLF1 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Borg J, et al. Nat Genet, 2010 Sep. PMID 20676099.KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. Zhou D, et al. Nat Genet, 2010 Sep. PMID 20676097.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Ganesh SK, et al. Nat Genet, 2009 Nov. PMID 19862010.Distinct modes of gene regulation by a cell-specific transcriptional activator. Sengupta T, et al. Proc Natl Acad Sci U S A, 2009 Mar 17. PMID 19251649.
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