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LAMA5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant LAMA5.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15230 |
| Other Accession | BC003355 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2F7 |
| Calculated MW | 399737 Da |
| Gene ID | 3911 |
|---|---|
| Other Names | Laminin subunit alpha-5, Laminin-10 subunit alpha, Laminin-11 subunit alpha, Laminin-15 subunit alpha, LAMA5, KIAA0533, KIAA1907 |
| Target/Specificity | LAMA5 (AAH03355.1, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | LAMA5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq]
References
1.Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion.Little GH, Noushmehr H, Baniwal SK, Berman BP, Coetzee GA, Frenkel B.Nucleic Acids Res. 2011 Dec 19.2.Melanoma cells produce multiple laminin isoforms and strongly migrate on ?5 laminin(s) via several integrin receptors.Oikawa Y, Hansson J, Sasaki T, Rousselle P, Domogatskaya A, Rodin S, Tryggvason K, Patarroyo M.Exp Cell Res. 2010 Dec 31. [Epub ahead of print]3.Proteomics Analysis of Nasopharyngeal Carcinoma Cell Secretome Using a Hollow Fiber Culture System and Mass Spectrometry.Wu HY, Chang YH, Chang YC, Liao PC.J Proteome Res. 2009 Jan;8(1):380-9.4.Proteomic analysis of platelet a-granules using mass spectrometry.Maynard DM, Heijnen HF, Horne MK, White JG, Gahl WA.J Thromb Haemost. 2007 Sep;5(9):1945-55.
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