LOC51255 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant RNF181.
|Application ||WB, IP, E|
|Calculated MW||17909 Da|
|Other Names||E3 ubiquitin-protein ligase RNF181, 632-, RING finger protein 181, RNF181|
|Target/Specificity||RNF181 (NP_057578, 90 a.a. ~ 153 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||LOC51255 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).
[Construction of recombinant eukaryotic expression vector pDsRed1-C3/LOC51255 and subcellular localization of LOC51255 protein in HePG2 cell line] Huang X, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2009 May. PMID 19426595.RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3. Brophy TM, et al. Biochem Biophys Res Commun, 2008 May 16. PMID 18331836.Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791.ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation. Larkin D, et al. J Biol Chem, 2004 Jun 25. PMID 15075326.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
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