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MAN1B1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MAN1B1.
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q9UKM7 |
| Other Accession | NM_016219 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 6B1 |
| Calculated MW | 79580 Da |
| Gene ID | 11253 |
|---|---|
| Other Names | Endoplasmic reticulum mannosyl-oligosaccharide 1, 2-alpha-mannosidase, ER alpha-1, 2-mannosidase, ER mannosidase 1, ERMan1, Man9GlcNAc2-specific-processing alpha-mannosidase, Mannosidase alpha class 1B member 1, MAN1B1 |
| Target/Specificity | MAN1B1 (NP_057303, 112 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MAN1B1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Polymorphism in the endoplasmic reticulum mannosidase I (MAN1B1) gene is not associated with liver disease in individuals homozygous for the Z variant of the alpha1-antitrypsin protease inhibitor (PiZZ individuals). Chappell S, et al. Hepatology, 2009 Oct. PMID 19739260.Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency. Pan S, et al. Hepatology, 2009 Jul. PMID 19444872.Theory and computation show that Asp463 is the catalytic proton donor in human endoplasmic reticulum alpha-(1-->2)-mannosidase I. Cant? D, et al. Carbohydr Res, 2008 Sep 8. PMID 18619586.Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation. Avezov E, et al. Mol Biol Cell, 2008 Jan. PMID 18003979.Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases. Hosokawa N, et al. Biochem Biophys Res Commun, 2007 Oct 26. PMID 17727818.
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