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MAPKAPK2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MAPKAPK2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, IP, E |
|---|---|
| Primary Accession | P49137 |
| Other Accession | NM_032960 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2B3 |
| Calculated MW | 45568 Da |
| Gene ID | 9261 |
|---|---|
| Other Names | MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAP-K2, MAPKAPK-2, MK-2, MK2, MAPKAPK2 |
| Target/Specificity | MAPKAPK2 (NP_116584, 302 a.a. ~ 400 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MAPKAPK2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
References
TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. Gais P, et al. J Immunol, 2010 May 15. PMID 20375303.p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Cannell IG, et al. Proc Natl Acad Sci U S A, 2010 Mar 23. PMID 20212154.MK2 signaling: lessons on tissue specificity in modulation of inflammation. Fyhrquist N, et al. J Invest Dermatol, 2010 Feb. PMID 20081887.p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Kumar B, et al. Cancer Res, 2010 Jan 15. PMID 20068172.The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response. Saenz JB, et al. Cell Microbiol, 2010 Apr 1. PMID 19951368.
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