MMRN1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant MMRN1.
|Application ||WB, E|
|Calculated MW||138110 Da|
|Other Names||Multimerin-1, EMILIN-4, Elastin microfibril interface located protein 4, Elastin microfibril interfacer 4, Endothelial cell multimerin, Platelet glycoprotein Ia*, 155 kDa platelet multimerin, p-155, p155, MMRN1, ECM, EMILIN4, GPIA*, MMRN|
|Target/Specificity||MMRN1 (NP_031377, 291 a.a. ~ 390 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MMRN1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Genome-wide association study reveals genetic risk underlying Parkinson's disease. Sim?n-S?nchez J, et al. Nat Genet, 2009 Dec. PMID 19915575.Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear. Tasneem S, et al. J Thromb Haemost, 2009 Apr. PMID 19175495.Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation. Jeimy SB, et al. Thromb Haemost, 2008 Dec. PMID 19132231.Location of the multimerin 1 binding site in coagulation factor V: an update. Jeimy SB, et al. Thromb Res, 2008. PMID 18452976.
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