MRC2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MRC2.
|Calculated MW||166674 Da|
|Other Names||C-type mannose receptor 2, C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, UPAR-associated protein, Urokinase receptor-associated protein, CD280, MRC2, CLEC13E, ENDO180, KIAA0709, UPARAP|
|Target/Specificity||MRC2 (NP_006030, 105 a.a. ~ 214 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MRC2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).
Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. Messaritou G, et al. J Cell Sci, 2009 Nov 15. PMID 19861500.Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. Wu X, et al. Cancer Prev Res (Phila), 2009 Jul. PMID 19584075.The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Wienke D, et al. Cancer Res, 2007 Nov 1. PMID 17974964.Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer. Sulek J, et al. J Histochem Cytochem, 2007 Apr. PMID 17189524.HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription. Caldwell RL, et al. Arch Biochem Biophys, 2006 May 15. PMID 16615932.
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