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>   home   >   Products   >   Primary Antibodies   >   MUTYH Antibody (monoclonal) (M01)   

MUTYH Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant MUTYH.

  • IP - MUTYH Antibody (monoclonal) (M01) AT2939a
    Immunoprecipitation of MUTYH transfected lysate using anti-MUTYH monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with MUTYH MaxPab rabbit polyclonal antibody.
  • WB - MUTYH Antibody (monoclonal) (M01) AT2939a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • WB - MUTYH Antibody (monoclonal) (M01) AT2939a
    MUTYH monoclonal antibody (M01), clone 4D10 Western Blot analysis of MUTYH expression in Hela S3 NE ( (Cat # AT2939a )
  • WB - MUTYH Antibody (monoclonal) (M01) AT2939a
    Western Blot analysis of MUTYH expression in transfected 293T cell line by MUTYH monoclonal antibody (M01), clone 4D10.

    Lane 1: MUTYH transfected lysate(59.1 KDa).
    Lane 2: Non-transfected lysate.
  • WB - MUTYH Antibody (monoclonal) (M01) AT2939a
    Western blot analysis of MUTYH over-expressed 293 cell line, cotransfected with MUTYH Validated Chimera RNAi ( (Cat # AT2939a )
  • E - MUTYH Antibody (monoclonal) (M01) AT2939a
    Detection limit for recombinant GST tagged MUTYH is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UIF7
Other Accession BC003178
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 4D10
Calculated MW 60069 Da
Additional Information
Gene ID 4595
Other Names A/G-specific adenine DNA glycosylase, 322-, MutY homolog, hMYH, MUTYH, MYH
Target/Specificity MUTYH (AAH03178, 436 a.a. ~ 535 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsMUTYH Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.


1.Impaired 8-Hydroxyguanine Repair Activity of MUTYH Variant p.Arg109Trp Found in a Japanese Patient with Early-Onset Colorectal Cancer.Shinmura K, Goto M, Tao H, Kato H, Suzuki R, Nakamura S, Matsuda T, Yin G, Morita M, Kono S, Sugimura HOxid Med Cell Longev. 2014;2014:617351. doi: 10.1155/2014/617351. Epub 2014 Mar 23.2.Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.Hahm SH, Chung JH, Agustina L, Han SH, Yoon IS, Park JH, Kang LW, Park JW, Na JJ, Han YS.Oncol Lett. 2012 Dec;4(6):1203-1208. Epub 2012 Sep 19.3.Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.Raetz AG, Xie Y, Kundu S, Brinkmeyer MK, Chang C, David SS.Carcinogenesis. 2012 Sep 20. [Epub ahead of print]4.Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.Shinmura K, Goto M, Suzuki M, Tao H, Yamada H, Igarashi H, Matsuura S, Maeda M, Konno H, Matsuda T, Sugimura H.The Journal of Pathology DOI: 10.1002 /path.29535.Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine.Suzuki T, Harashima H, Kamiya H.DNA Repair (Amst). 2010 Feb 28. [Epub ahead of print]6.Immunohistochemistry is not an accurate first step towards the molecular diagnosis of MUTYH-associated polyposis.van der Post RS, Kets CM, Ligtenberg MJ, van Krieken JH, Hoogerbrugge N.Virchows Arch. 2009 Jan;454(1):25-9. Epub 2008 Nov 25.

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$ 350.00
Cat# AT2939a
Availability: 7-10 days
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