MUTYH Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MUTYH.
|Application ||WB, IP, E|
|Calculated MW||60069 Da|
|Other Names||A/G-specific adenine DNA glycosylase, 322-, MutY homolog, hMYH, MUTYH, MYH|
|Target/Specificity||MUTYH (AAH03178, 436 a.a. ~ 535 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MUTYH Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
1.Impaired 8-Hydroxyguanine Repair Activity of MUTYH Variant p.Arg109Trp Found in a Japanese Patient with Early-Onset Colorectal Cancer.Shinmura K, Goto M, Tao H, Kato H, Suzuki R, Nakamura S, Matsuda T, Yin G, Morita M, Kono S, Sugimura HOxid Med Cell Longev. 2014;2014:617351. doi: 10.1155/2014/617351. Epub 2014 Mar 23.2.Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.Hahm SH, Chung JH, Agustina L, Han SH, Yoon IS, Park JH, Kang LW, Park JW, Na JJ, Han YS.Oncol Lett. 2012 Dec;4(6):1203-1208. Epub 2012 Sep 19.3.Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.Raetz AG, Xie Y, Kundu S, Brinkmeyer MK, Chang C, David SS.Carcinogenesis. 2012 Sep 20. [Epub ahead of print]4.Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.Shinmura K, Goto M, Suzuki M, Tao H, Yamada H, Igarashi H, Matsuura S, Maeda M, Konno H, Matsuda T, Sugimura H.The Journal of Pathology DOI: 10.1002 /path.29535.Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine.Suzuki T, Harashima H, Kamiya H.DNA Repair (Amst). 2010 Feb 28. [Epub ahead of print]6.Immunohistochemistry is not an accurate first step towards the molecular diagnosis of MUTYH-associated polyposis.van der Post RS, Kets CM, Ligtenberg MJ, van Krieken JH, Hoogerbrugge N.Virchows Arch. 2009 Jan;454(1):25-9. Epub 2008 Nov 25.
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