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NGB Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant NGB.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NPG2 |
| Other Accession | BC032509 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1A11-A9 |
| Calculated MW | 16933 Da |
| Gene ID | 58157 |
|---|---|
| Other Names | Neuroglobin, NGB |
| Target/Specificity | NGB (AAH32509, 1 a.a. ~ 151 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NGB Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.
References
Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury. Chuang PY, et al. J Neurotrauma, 2010 Jun. PMID 20345238.Spectroscopic study on acid-induced unfolding and refolding of apo-neuroglobin. Mu J, et al. Spectrochim Acta A Mol Biomol Spectrosc, 2010 May. PMID 20227336.Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Raychaudhuri S, et al. Apoptosis, 2010 Apr. PMID 20091232.Neuroglobin expression in ischemic stroke. Jin K, et al. Stroke, 2010 Mar. PMID 20075359.Unusual stability of human neuroglobin at low pH--molecular mechanisms and biological significance. Picotti P, et al. FEBS J, 2009 Dec. PMID 19860834.
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