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OCRL Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant OCRL.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q01968 |
| Other Accession | NM_000276 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4A6 |
| Calculated MW | 104205 Da |
| Gene ID | 4952 |
|---|---|
| Other Names | Inositol polyphosphate 5-phosphatase OCRL-1, Lowe oculocerebrorenal syndrome protein, OCRL, INPP5F, OCRL1 |
| Target/Specificity | OCRL (NP_000267, 146 a.a. ~ 239 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | OCRL Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.
References
Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1. Swan LE, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133602.Development of a multiplex ligation-dependent probe amplification (MLPA) assay for quantification of the OCRL1 gene. Coutton C, et al. Clin Biochem, 2010 Apr. PMID 20043897.OCRL1 function in renal epithelial membrane traffic. Cui S, et al. Am J Physiol Renal Physiol, 2010 Feb. PMID 19940034.Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase. Coon BG, et al. Hum Mol Genet, 2009 Dec 1. PMID 19700499.Locus heterogeneity of Dent's disease: OCRL1 and TMEM27 genes in patients with no CLCN5 mutations. Tosetto E, et al. Pediatr Nephrol, 2009 Oct. PMID 19582483.
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