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PAX2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant PAX2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q02962 |
| Other Accession | NM_000278 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2E5 |
| Calculated MW | 44706 Da |
| Gene ID | 5076 |
|---|---|
| Other Names | Paired box protein Pax-2, PAX2 |
| Target/Specificity | PAX2 (NP_000269, 194 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PAX2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
References
1.c-Jun is essential for the induction of Il-1?] gene expression in in vitro activated Bergmann glial cells.Albanito L, Reddy CE, Musti AM.Glia. 2011 Sep 21. doi: 10.1002/glia.21244.2.The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.Doberstein K, Pfeilschifter J, Gutwein P.Carcinogenesis. 2011 Sep 16.
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