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PNPLA2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PNPLA2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96AD5 |
| Other Accession | NM_020376 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2H1 |
| Calculated MW | 55316 Da |
| Gene ID | 57104 |
|---|---|
| Other Names | Patatin-like phospholipase domain-containing protein 2, Adipose triglyceride lipase, Calcium-independent phospholipase A2, Desnutrin, IPLA2-zeta, Pigment epithelium-derived factor, TTS22, Transport-secretion protein 2, TTS2, PNPLA2, ATGL |
| Target/Specificity | PNPLA2 (NP_065109, 347 a.a. ~ 446 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PNPLA2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.
References
High frequency of ETFDH c.250G>A mutation in Taiwanese patients with late-onset lipid storage myopathy. Lan MY, et al. Clin Genet, 2010 Mar 29. PMID 20370797.Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit. Johansen CT, et al. Int J Circumpolar Health, 2010 Feb. PMID 20167152.Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis. B?zaire V, et al. FEBS Lett, 2009 Sep 17. PMID 19695247.Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells. Duncan RE, et al. J Lipid Res, 2010 Feb. PMID 19692632.Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes. Bezaire V, et al. J Biol Chem, 2009 Jul 3. PMID 19433586.
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