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POLR2D Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant POLR2D.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O15514 |
| Other Accession | BC017205 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1E4-A5 |
| Calculated MW | 16311 Da |
| Gene ID | 5433 |
|---|---|
| Other Names | DNA-directed RNA polymerase II subunit RPB4, RNA polymerase II subunit B4, DNA-directed RNA polymerase II subunit D, RNA polymerase II 16 kDa subunit, RPB16, POLR2D |
| Target/Specificity | POLR2D (AAH17205, 1 a.a. ~ 142 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | POLR2D Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene.
References
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Michiels S, et al. Carcinogenesis, 2009 May. PMID 19237606.Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375.Will diverse Tat interactions lead to novel antiretroviral drug targets? Harrich D, et al. Curr Drug Targets, 2006 Dec. PMID 17168834.The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention. Stevens M, et al. Med Res Rev, 2006 Sep. PMID 16838299.Inhibition of HIV-1 virus replication using small soluble Tat peptides. Agbottah E, et al. Virology, 2006 Feb 20. PMID 16289656.
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