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S100A2 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant S100A2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P29034 |
| Other Accession | BC002829 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3H8 |
| Calculated MW | 11117 Da |
| Gene ID | 6273 |
|---|---|
| Other Names | Protein S100-A2, CAN19, Protein S-100L, S100 calcium-binding protein A2, S100A2, S100L |
| Target/Specificity | S100A2 (AAH02829, 1 a.a. ~ 97 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | S100A2 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer.
References
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.S100 proteins interact with the N-terminal domain of MDM2. van Dieck J, et al. FEBS Lett, 2010 Aug 4. PMID 20591429.Expression and clinical significance of S100A2 and p63 in esophageal carcinoma. Cao LY, et al. World J Gastroenterol, 2009 Sep 7. PMID 19725154.Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. Stemmler S, et al. Int J Immunogenet, 2009 Aug. PMID 19601998.Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer. Biankin AV, et al. Gastroenterology, 2009 Aug. PMID 19376121.
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