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SIX2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SIX2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q9NPC8 |
| Other Accession | BC024033 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 3D7 |
| Calculated MW | 32286 Da |
| Gene ID | 10736 |
|---|---|
| Other Names | Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX2 |
| Target/Specificity | SIX2 (AAH24033, 1 a.a. ~ 291 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SIX2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development.
References
1.Mdm2 is required for maintenance of the nephrogenic niche.Hilliard SA, Yao X, El-Dahr SSDev Biol. 2014 Jan 17. pii: S0012-1606(14)00024-4. doi: 10.1016/j.ydbio.2014.01.009.2.SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.Murphy AJ, Pierce J, de Caestecker C, Taylor C, Anderson JR, Perantoni AO, de Caestecker MP, Lovvorn HN 3rd.J Pediatr Surg. 2012 Jun;47(6):1239-49.3.Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy.Lee SH, Kim J, Ryu JY, Lee S, Yang DK, Jeong D, Kim J, Lee SH, Kim JM, Hajjar RJ, Park WJ.J Mol Cell Cardiol. 2011 Dec 14.
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