SPAG5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SPAG5.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q96R06 |
Other Accession | BC000322 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG3 Kappa |
Clone Names | 5F9 |
Calculated MW | 134422 Da |
Gene ID | 10615 |
---|---|
Other Names | Sperm-associated antigen 5, Astrin, Deepest, Mitotic spindle-associated protein p126, MAP126, SPAG5 |
Target/Specificity | SPAG5 (AAH00322, 1082 a.a. ~ 1191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | SPAG5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
References
Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint. Liu L, et al. Cell Cycle, 2009 Feb 15. PMID 19197158.Astrin regulates Aurora-A localization. Du J, et al. Biochem Biophys Res Commun, 2008 May 30. PMID 18361916.Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin. Cheng TS, et al. J Biol Chem, 2008 Jan 25. PMID 18055457.Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. Thein KH, et al. J Cell Biol, 2007 Jul 30. PMID 17664331.
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