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TXNDC3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TXNDC3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8N427 |
| Other Accession | NM_016616 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1G5 |
| Calculated MW | 67270 Da |
| Gene ID | 51314 |
|---|---|
| Other Names | Thioredoxin domain-containing protein 3, NM23-H8, NME/NM23 family member 8, Spermatid-specific thioredoxin-2, Sptrx-2, NME8, SPTRX2, TXNDC3 |
| Target/Specificity | TXNDC3 (NP_057700, 530 a.a. ~ 586 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TXNDC3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. Zintzaras E, et al. Am J Epidemiol, 2010 Apr 15. PMID 20237151.Nme protein family evolutionary history, a vertebrate perspective. Desvignes T, et al. BMC Evol Biol, 2009 Oct 23. PMID 19852809.Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis. Shi D, et al. Arthritis Res Ther, 2008. PMID 18471322.A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia. Duriez B, et al. Proc Natl Acad Sci U S A, 2007 Feb 27. PMID 17360648.
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