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FITC Anti-Human CD45 (2D1) Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC |
|---|---|
| Isotype | Mouse IgG1, kappa |
| Concentration | 5 µL (1 µg)/test |
| Reactivity | Human |
| Formulation | 10mM NaH2PO4, 150 mM NaCl, 0.09% NaN3,0.1%gelatin,pH7.2 0.1% gelatin, pH7.2 |
| Gene ID | 5788 |
|---|---|
| Gene Name | PTPRC |
| Alternative Name(s) | Leukocyte Common Antigen, LCA, Ly-5, Hle-1 |
| Format | FITC |
| Storage Conditions | 2-8°C protected from light |
Provided below are standard protocols that you may find useful for product applications.
Background
The 2D1 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and CD45RO. The 2D1 antibody is widely used as a marker for human CD45 expression on peripheral blood T cells, B cells, monocytes, macrophages, and NK cells
References
Bradstock KF, Janossy G, Pizzolo G, Hoffbrand AV, McMichael A, Pilch JR, Milstein C, Beverley P and Bollum FJ. 1980. J. Natl. Cancer Inst. 65(1): 33-42.
Schwinzer R. in Knapp W, Dorken B, et al. eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York. p. 628-634.
Nieminen JK, Sipponen T, Färkkilä M and Vaarala O. 2014. Clin. Exp. Immunol. 177(1): 190-202. (Flow Cytometry)
Piątosa B, Wolska-Kuśnierz B, Pac M, Siewiera K, Gałkowska E and Bernatowska E. 2010. Cytometry Part B. 78B: 372-381. (Flow Cytometry)
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