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HSF2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q03933 |
| Other Accession | NP_004497.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=60,58;M=60,58 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 3298 |
|---|---|
| Antigen Region | 216-245 aa |
| Other Names | HSF2; HSTF2; Heat shock factor protein 2; Heat shock transcription factor 2 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This HSF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the Central region of human HSF2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HSF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HSF2 |
|---|---|
| Synonyms | HSTF2 |
| Function | DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. |
| Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation |
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Provided below are standard protocols that you may find useful for product applications.
Background
HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xing, H., et al. Cell Stress Chaperones 15(3):301-308(2010)
Sandqvist, A., et al. Mol. Biol. Cell 20(5):1340-1347(2009)
Tateishi, Y., et al. J. Biol. Chem. 284(4):2435-2447(2009)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
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