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COPS2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| IF, IHC-P, WB |
|---|---|
| Primary Accession | P61201 |
| Other Accession | Q6IR75, P61203, P61202, Q6IQT4, NP_004227.1 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Zebrafish, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=52;M=52;Rat=52,47 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 9318 |
|---|---|
| Antigen Region | 1-30 aa |
| Other Names | COPS2; CSN2; TRIP15; COP9 signalosome complex subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15 |
| Dilution | IF~~1:25 WB~~1:1000 IHC-P~~1:10~50 |
| Target/Specificity | This COPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human COPS2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | COPS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COPS2 |
|---|---|
| Synonyms | CSN2, TRIP15 |
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. |
| Cellular Location | Cytoplasm. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
References
Kob, R., et al. Cell Cycle 8(13):2041-2049(2009)
Leal, J.F., et al. Oncogene 27(14):1961-1970(2008)
Fegers, I., et al. J. Proteome Res. 6(11):4182-4188(2007)
Tenbaum, S.P., et al. Biochim. Biophys. Acta 1773(9):1447-1454(2007)
Papaioannou, M., et al. Nucl Recept Signal 5, E008 (2007) :
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