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Anti-Glargine Insulin polyclonal antibody
Purified Guinea pig polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| swELISA |
|---|---|
| Host | Guinea Pig |
| Clonality | Polyclonal |
| Antigen Source | Insulin glargine, marketed under the names Lantus, among others, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes. Insulin glargine has a substitution of glycine for asparagine at N21 (Asn21) and two arginines added to the carboxy terminal of B chain. The arginine amino acids shift the isoelectric point from a pH of 5.4 to 6.7, making the molecule more soluble at an acidic pH and less soluble at physiological pH. The isoelectric shift also allows for the subcutaneous injection of a clear solution. The glycine substitution prevents deamidation of the acid-sensitive asparagine at acidic pH. In the neutral subcutaneous space, higher-order aggregates form, resulting in a slow, peakless dissolution and absorption of insulin from the site of injection. It can achieve a peakless level for at least 24 hours. Molecular formula: C267H404N72O78S6 Molecular weight:6063 |
| Other Names | Anti-Glargine Insulin polyclonal antibody |
|---|---|
| Target/Specificity | Guinea pig polyclonal antibody raised against Glargine Insulin . |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a antigen affinity purification column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Glargine Insulin polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Research Areas
Citations (0)
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Application Protocols
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$ 370.00
Cat# AW5686-U100
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