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GPAM Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HCL2 |
|---|---|
| Other Accession | NP_065969.3 |
| Clone Names | 90805037 |
| Gene ID | 57678 |
|---|---|
| Other Names | Glycerol-3-phosphate acyltransferase 1, mitochondrial, GPAT-1, GPAM, GPAT1, KIAA1560 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GPAM (HGNC:24865) |
|---|---|
| Function | Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids (PubMed:18238778, PubMed:19075029, PubMed:36522428). Esterifies acyl-group from acyl- coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid (PubMed:18238778). Has a narrow hydrophobic binding cleft that selects for a linear acyl chain (PubMed:36522428). Catalytic activity is higher for substrates with a 16-carbon acyl chain (PubMed:36522428). |
| Cellular Location | Mitochondrion outer membrane; Peripheral membrane protein. Note=Associated with the mitochondrion outer membrane of hepatic cells via a patch of basic residues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Glycerol-3-phosphate acyltransferase (GPAT; EC 2.3.1.15),which catalyzes the initial and committing step in glycerolipidbiosynthesis, is predicted to play a pivotal role in the regulationof cellular triacylglycerol and phospholipid levels. Two mammalianforms of GPAT have been identified on the basis of localization toeither the endoplasmic reticulum or mitochondria.[supplied byOMIM].
References
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Chen, Y.Q., et al. J. Biol. Chem. 283(15):10048-10057(2008)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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