DAGLA Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y4D2 |
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Other Accession | NP_006124.1 |
Clone Names | 91230209 |
Gene ID | 747 |
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Other Names | Sn1-specific diacylglycerol lipase alpha, DGL-alpha, 311-, Neural stem cell-derived dendrite regulator, DAGLA, C11orf11, KIAA0659, NSDDR |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DAGLA |
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Synonyms | C11orf11, KIAA0659, NSDDR {ECO:0000303|R |
Function | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2- arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q6WQJ1}; Multi-pass membrane protein. Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner |
Tissue Location | Highly expressed in brain and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a diacylglycerol lipase. The encodedenzyme is involved in the biosynthesis of the endocannabinoid2-arachidonoyl-glycerol.
References
Knight, M.A., et al. Hum. Mol. Genet. 17(24):3847-3853(2008)Jung, K.M., et al. Mol. Pharmacol. 68(5):1196-1202(2005)Bisogno, T., et al. J. Cell Biol. 163(3):463-468(2003)
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