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MICALL1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N3F8 |
|---|---|
| Other Accession | NP_203744.1 |
| Clone Names | 91102067 |
| Gene ID | 85377 |
|---|---|
| Other Names | MICAL-like protein 1, Molecule interacting with Rab13, MIRab13, MICALL1, KIAA1668, MIRAB13 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MICALL1 |
|---|---|
| Synonyms | KIAA1668, MIRAB13 |
| Function | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). |
| Cellular Location | Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane. Cell projection, cilium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6 (PubMed:21951725). Interaction with tubulins achors MICALL1 to the centriole (PubMed:31615969). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MICALL1 may be a cytoskeletal regulator.
References
Sharma, M., et al. Mol. Biol. Cell 20(24):5181-5194(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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