P5F1B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q06416 |
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Clone Names | 91208194 |
Gene ID | 5462 |
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Other Names | Putative POU domain, class 5, transcription factor 1B, Oct4-pg1, Octamer-binding protein 3-like, Octamer-binding transcription factor 3-like, POU5F1B |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | POU5F1B |
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Function | Shows weak transcriptional activator activity. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:18949397} |
Tissue Location | Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
This intronless gene was thought to be a transcribedpseudogene of POU class 5 homeobox 1, however, it has been reportedthat this gene can encode a functional protein. The encoded proteinis nearly the same length as and highly similar to the POU class 5homeobox 1 transcription factor, has been shown to be a weaktranscriptional activator and may play a role in carcinogenesis andeye development.
References
Kastler, S., et al. Prostate 70(6):666-674(2010)White, K.L., et al. Twin Res Hum Genet 13(1):43-56(2010)Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)Gudmundsson, J., et al. Nat. Genet. 41(10):1122-1126(2009)Panagopoulos, I., et al. Oncol. Rep. 20(5):1029-1033(2008)
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