SEC11C Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BY50 |
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Clone Names | 100120108 |
Gene ID | 90701 |
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Other Names | Signal peptidase complex catalytic subunit SEC11C, Microsomal signal peptidase 21 kDa subunit, SPase 21 kDa subunit, SEC11 homolog C, SEC11-like protein 3, SPC21, SEC11C, SEC11L3, SPC21, SPCS4C |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SEC11C |
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Synonyms | SEC11L3, SPC21, SPCS4C |
Function | Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N- terminal signal peptides that contain a hydrophobic alpha-helix (h- region) shorter than 18-20 amino acids (PubMed:34388369). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13679}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P13679} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)Dodson, G., et al. Curr. Opin. Struct. Biol. 8(2):189-194(1998)
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