INPP5E Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NRR6 |
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Clone Names | 80513214 |
Gene ID | 56623 |
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Other Names | 72 kDa inositol polyphosphate 5-phosphatase, Phosphatidylinositol 4, 5-bisphosphate 5-phosphatase, Phosphatidylinositol polyphosphate 5-phosphatase type IV, INPP5E |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | INPP5E |
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Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10764818) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). |
Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Nucleus {ECO:0000250|UniProtKB:Q9JII1} Note=Peripheral membrane protein associated with Golgi stacks {ECO:0000250|UniProtKB:Q9JII1} |
Tissue Location | Detected in brain, heart, pancreas, testis and spleen. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an inositol1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphataseshydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium andacts as a second messenger mediating cell responses to variousstimulation. Studies of the mouse counterpart suggest that thisprotein may hydrolyze phosphatidylinositol 3,4, 5-trisphosphate andphosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgimembrane and thereby regulate Golgi-vesicular trafficking.
References
Bielas, S.L., et al. Nat. Genet. 41(9):1032-1036(2009)Jacoby, M., et al. Nat. Genet. 41(9):1027-1031(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)Kong, A.M., et al. J. Biol. Chem. 275(31):24052-24064(2000)
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