JUNB Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P17275 |
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Clone Names | 81202057 |
Gene ID | 3726 |
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Other Names | Transcription factor jun-B, JUNB |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | JUNB |
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Function | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transcription factor that is a memberof the leucine zipper family of DNA binding proteins. This proteinbinds as a homodimer to the cAMP-responsive element, an octamericpalindrome. The protein is phosphorylated by several proteinkinases, and induces transcription of genes in response to hormonalstimulation of the cAMP pathway. Alternate splicing of this generesults in two transcript variants encoding different isoforms.
References
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Chen, G., et al. J. Neurosci. 30(39):13066-13077(2010)Serretti, A., et al. J Affect Disord (2010) In press :Melnikova, V.O., et al. PLoS ONE 5 (8), E12452 (2010) :
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