MSI1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O43347 |
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Clone Names | 80513001 |
Gene ID | 4440 |
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Other Names | RNA-binding protein Musashi homolog 1, Musashi-1, MSI1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MSI1 |
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Function | RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU- 3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q61474}. Nucleus {ECO:0000250|UniProtKB:Q61474} |
Tissue Location | Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein containing two conservedtandem RNA recognition motifs. Similar proteins in other speciesfunction as RNA-binding proteins and play central roles inposttranscriptional gene regulation. Expression of this gene hasbeen correlated with the grade of the malignancy and proliferativeactivity in gliomas and melanomas. A pseudogene for this gene islocated on chromosome 11q13.
References
Fan, L.F., et al. Int J Colorectal Dis 25(1):17-23(2010)de Sousa Abreu, R., et al. J. Biol. Chem. 284(18):12125-12135(2009)Murayama, M., et al. J. Gastroenterol. 44(3):173-182(2009)Gotte, M., et al. J. Pathol. 215(3):317-329(2008)Sanchez-Diaz, P.C., et al. BMC Cancer 8, 280 (2008) :
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