TBX6 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95947 |
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Clone Names | 71009106 |
Gene ID | 6911 |
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Other Names | T-box transcription factor TBX6, T-box protein 6, TBX6 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TBX6 |
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Function | T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. |
Tissue Location | Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of a phylogenetically conservedfamily of genes that share a common DNA-binding domain, the T-box.T-box genes encode transcription factors involved in the regulationof developmental processes. Knockout studies in mice indicate thatthis gene is important for specification of paraxial mesodermstructures.
References
Fei, Q., et al. Spine 35(9):983-988(2010)Ghebranious, N., et al. J. Bone Miner. Res. 23(10):1576-1583(2008)Farin, H.F., et al. J. Biol. Chem. 282(35):25748-25759(2007)Papapetrou, C., et al. Genomics 55(2):238-241(1999)Yi, C.H., et al. Genomics 55(1):10-20(1999)
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