SIX5 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N196 |
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Clone Names | 100324152 |
Gene ID | 147912 |
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Other Names | Homeobox protein SIX5, DM locus-associated homeodomain protein, Sine oculis homeobox homolog 5, SIX5, DMAHP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SIX5 |
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Synonyms | DMAHP |
Function | Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). |
Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12500905} |
Tissue Location | Expressed in adult but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is ahomeodomain-containing transcription factor that appears tofunction in the regulation of organogenesis. This gene is locateddownstream of the dystrophia myotonica-protein kinase gene.Mutations in this gene are a cause of branchiootorenal syndrometype 2.
References
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Hoskins, B.E., et al. Am. J. Hum. Genet. 80(4):800-804(2007)Sato, S., et al. Hum. Mol. Genet. 11(9):1045-1058(2002)Fougerousse, F., et al. J. Muscle Res. Cell. Motil. 23(3):255-264(2002)
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