ARHGAP22 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q7Z5H3 |
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Clone Names | 91216030 |
Gene ID | 58504 |
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Other Names | Rho GTPase-activating protein 22, Rho-type GTPase-activating protein 22, ARHGAP22, RHOGAP2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ARHGAP22 |
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Synonyms | RHOGAP2 |
Function | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). |
Cellular Location | Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity) |
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Provided below are standard protocols that you may find useful for product applications.
Background
ARHGAPs, such as ARHGAP22, encode negative regulators ofRho GTPases (see ARHA; MIM 165390), which are implicated in actinremodeling, cell polarity, and cell migration (Katoh and Katoh,2004 [PubMed 15254788]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Dick, D.M., et al. Mol. Psychiatry (2010) In press :Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Katoh, M., et al. Int. J. Mol. Med. 14(2):333-338(2004)
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