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ACADL Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P28330 |
|---|---|
| Clone Names | 100324213 |
| Gene ID | 33 |
|---|---|
| Other Names | Long-chain specific acyl-CoA dehydrogenase, mitochondrial, LCAD, ACADL |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13134a was selected from the N-term region of ACADL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ACADL (HGNC:88) |
|---|---|
| Function | Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl- CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:21237683, PubMed:8823175). |
| Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:P15650} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the acyl-CoAdehydrogenase family, which is a family of mitochondrialflavoenzymes involved in fatty acid and branched chain amino-acidmetabolism. This protein is one of the four enzymes that catalyzethe initial step of mitochondrial beta-oxidation of straight-chainfatty acid. Defects in this gene are the cause of long-chainacyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotichypoglycemia.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Maher, A.C., et al. Mol. Genet. Metab. 100(2):163-167(2010)Illig, T., et al. Nat. Genet. 42(2):137-141(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
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