SGEF Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96DR7 |
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Clone Names | 100416053 |
Gene ID | 26084 |
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Other Names | Rho guanine nucleotide exchange factor 26, SH3 domain-containing guanine exchange factor, ARHGEF26, SGEF |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13325c was selected from the Center region of SGEF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ARHGEF26 |
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Synonyms | SGEF |
Function | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. |
Cellular Location | Cell projection, ruffle |
Tissue Location | Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
SGEF activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
References
Yamada, S., et al. Oncogene 23(35):5901-5911(2004)Ellerbroek, S.M., et al. Mol. Biol. Cell 15(7):3309-3319(2004)Qi, H., et al. Endocrinology 144(5):1742-1752(2003)
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