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TBCC Antibody (N-term ) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15814 |
|---|---|
| Clone Names | 100416009 |
| Gene ID | 6903 |
|---|---|
| Other Names | Tubulin-specific chaperone C, Tubulin-folding cofactor C, CFC, TBCC |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13475a was selected from the N-term region of TBCC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TBCC |
|---|---|
| Function | Tubulin-folding protein; involved in the final step of the tubulin folding pathway. |
| Cellular Location | Cytoplasm. Note=Detected predominantly in the photoreceptor connecting cilium |
| Tissue Location | Expressed in the retina. Expressed in the rod and cone photoreceptors, extending from the inner segments (IS), through the outer nuclear layer (ONL) and into the synapses in the outer plexiform layer (OPL). Strongly expressed to the photoreceptor connecting cilium at the tips of the IS (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cofactor C is one of four proteins (cofactors A, D, E, andC) involved in the pathway leading to correctly folded beta-tubulinfrom folding intermediates. Cofactors A and D are believed to playa role in capturing and stabilizing beta-tubulin intermediates in aquasi-native confirmation. Cofactor E binds to the cofactorD/beta-tubulin complex; interaction with cofactor C then causes therelease of beta-tubulin polypeptides that are committed to thenative state.
References
Hage-Sleiman, R., et al. BMC Cancer 10, 135 (2010) :Nature 447(7145):661-678(2007)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Bartolini, F., et al. J. Biol. Chem. 277(17):14629-14634(2002)Tian, G., et al. Cell 86(2):287-296(1996)
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