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LDHA Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00338 |
|---|---|
| Clone Names | 100427085 |
| Gene ID | 3939 |
|---|---|
| Other Names | L-lactate dehydrogenase A chain, LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59, LDHA |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13542b was selected from the C-term region of LDHA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LDHA (HGNC:6535) |
|---|---|
| Function | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Predominantly expressed in anaerobic tissues such as skeletal muscle and liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes the conversionof L-lactate and NAD to pyruvate and NADH in the final step ofanaerobic glycolysis. The protein is found predominantly in muscletissue and belongs to the lactate dehydrogenase family. Mutationsin this gene have been linked to exertional myoglobinuria. Multipletranscript variants encoding different isoforms have been found forthis gene. The human genome contains several non-transcribedpseudogenes of this gene.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)Zhuang, L., et al. Mod. Pathol. 23(1):45-53(2010)Zhao, Y.H., et al. Oncogene 28(42):3689-3701(2009)Koukourakis, M.I., et al. Oncology 77(5):285-292(2009)
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