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CCR9 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P51686 |
|---|---|
| Clone Names | 100427314 |
| Gene ID | 10803 |
|---|---|
| Other Names | C-C chemokine receptor type 9, C-C CKR-9, CC-CKR-9, CCR-9, G-protein coupled receptor 28, GPR-9-6, CDw199, CCR9, GPR28 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13854b was selected from the C-term region of CCR9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CCR9 |
|---|---|
| Synonyms | GPR28 |
| Function | Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in the thymus and low in lymph nodes and spleen. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the betachemokine receptor family. It is predicted to be a seventransmembrane protein similar to G protein-coupled receptors.Chemokines and their receptors are key regulators of the thymocytesmigration and maturation in normal and inflammation conditions. Thespecific ligand of this receptor is CCL25. It has been found thatthis gene is differentially expressed by T lymphocytes of smallintestine and colon, suggested a role in the thymocytes recruitmentand development that may permit functional specialization of immuneresponses in different segment of the gastrointestinal tract. Thisgene is mapped to the chemokine receptor gene cluster region. Twoalternatively spliced transcript variants have been described.
References
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Wang, Y., et al. Cell. Mol. Immunol. 7(1):51-60(2010)
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