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Mouse Pak3 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q61036 |
|---|---|
| Clone Names | 110316310 |
| Gene ID | 18481 |
|---|---|
| Other Names | Serine/threonine-protein kinase PAK 3, Beta-PAK, CDC42/RAC effector kinase PAK-B, p21-activated kinase 3, PAK-3, Pak3, Pak-3, Pakb, Stk4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13931a was selected from the N-term region of Mouse Pak3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Pak3 |
|---|---|
| Synonyms | Pak-3, Pakb, Stk4 |
| Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity (PubMed:25851601). Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (PubMed:15800193). |
| Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Key regulator of synapse formation and plasticity in the hippocampus.
References
Shimogori, T., et al. Nat. Neurosci. 13(6):767-775(2010)Jiang, X.S., et al. Hum. Mol. Genet. 19(7):1347-1357(2010)Demyanenko, G.P., et al. Neuroscience 165(1):107-115(2010)Grimsley-Myers, C.M., et al. J. Neurosci. 29(50):15859-15869(2009)Sansom, S.N., et al. PLoS Genet. 5 (6), E1000511 (2009) :
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