Mouse Tp53rk Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99PW4 |
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Clone Names | 110328055 |
Other Names | TP53-regulating kinase, Atypical serine/threonine protein kinase Tp53rk, EKC/KEOPS complex subunit Tp53rk, 36--, Nori-2, p53-related protein kinase, Tp53rk, Prpk, Trp53rk |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Tp53rkb {ECO:0000305} |
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Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q96S44}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tp53rk is a protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).
References
Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :Abe, Y., et al. J. Biol. Chem. 276(47):44003-44011(2001)
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