S1PR5 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H228 |
---|---|
Clone Names | 100525069 |
Gene ID | 53637 |
---|---|
Other Names | Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | S1PR5 |
---|---|
Synonyms | EDG8 |
Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The lysosphingolipid sphingosine 1-phosphate (S1P)regulates cell proliferation, apoptosis, motility, and neuriteretraction. Its actions may be both intracellular as a secondmessenger and extracellular as a receptor ligand. S1P and thestructurally related lysolipid mediator lysophosphatidic acid (LPA)signal cells through a set of G protein-coupled receptors known asEDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1Preceptors; others (e.g., EDG2; MIM 602282) are LPAreceptors.
References
Chang, C.L., et al. Am. J. Physiol., Cell Physiol. 297 (2), C451-C458 (2009) :Gillies, L., et al. Cell. Signal. 21(5):675-684(2009)Miron, V.E., et al. Ann. Neurol. 63(1):61-71(2008)Ulfig, N., et al. Acta Histochem. 106(5):373-378(2004)Vogler, R., et al. J. Invest. Dermatol. 120(4):693-700(2003)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.