GRIK2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q13002 |
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Clone Names | 100525146 |
Gene ID | 2898 |
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Other Names | Glutamate receptor ionotropic, kainate 2, GluK2, Excitatory amino acid receptor 4, EAA4, Glutamate receptor 6, GluR-6, GluR6, GRIK2, GLUR6 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GRIK2 |
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Synonyms | GLUR6 |
Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). Modulates cell surface expression of NETO2 (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein |
Tissue Location | Expression is higher in cerebellum than in cerebral cortex |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glutamate receptors are the predominant excitatoryneurotransmitter receptors in the mammalian brain and are activatedin a variety of normal neurophysiologic processes. This geneproduct belongs to the kainate family of glutamate receptors, whichare composed of four subunits and function as ligand-activated ionchannels. The subunit encoded by this gene is subject to RNAediting at multiple sites within the first and second transmembranedomains, which is thought to alter the structure and function ofthe receptor complex. Alternatively spliced transcript variantsencoding different isoforms have also been described for this gene.Mutations in this gene have been associated with autosomalrecessive mental retardation.
References
Han, Y., et al. Biochemistry 49(43):9207-9216(2010)Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sampaio, A.S., et al. CNS Neurosci Ther (2010) In press :Sander, T., et al. Neurology 45(9):1713-1720(1995)
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