IMPDH1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P20839 |
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Clone Names | 100507305 |
Gene ID | 3614 |
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Other Names | Inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 1 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-I, IMPDH1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IMPDH1 {ECO:0000255|HAMAP-Rule:MF_03156} |
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Synonyms | IMPD1 |
Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016} |
Tissue Location | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene acts as a homotetramer toregulate cell growth. The encoded protein is an enzyme thatcatalyzes the synthesis of xanthine monophosphate (XMP) frominosine-5'-monophosphate (IMP). This is the rate-limiting step inthe de novo synthesis of guanine nucleotides. Defects in this geneare a cause of retinitis pigmentosa type 10 (RP10). Severaltranscript variants encoding different isoforms have been found forthis gene.
References
Ohmann, E.L., et al. Pediatr Transplant 14(7):891-895(2010)Gensburger, O., et al. Pharmacogenet. Genomics 20(9):537-543(2010)Kagaya, H., et al. Basic Clin. Pharmacol. Toxicol. 107(2):631-636(2010)Ohmann, E.L., et al. J. Heart Lung Transplant. 29(5):509-516(2010)Shumei, L., et al. Adv. Exp. Med. Biol. 664, 293-297 (2010) :
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