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LSM14A Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8ND56 |
|---|---|
| Clone Names | 100416132 |
| Gene ID | 26065 |
|---|---|
| Other Names | Protein LSM14 homolog A, Protein FAM61A, Protein SCD6 homolog, Putative alpha-synuclein-binding protein, AlphaSNBP, RNA-associated protein 55A, hRAP55, hRAP55A, LSM14A, C19orf13, FAM61A, RAP55, RAP55A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LSM14A {ECO:0000303|PubMed:26339800, ECO:0000312|HGNC:HGNC:24489} |
|---|---|
| Function | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). |
| Cellular Location | Cytoplasm, P-body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, Stress granule |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sm-like proteins were identified in a variety of organismsbased on sequence homology with the Sm protein family (see SNRPD2;601061). Sm-like proteins contain the Sm sequence motif, whichconsists of 2 regions separated by a linker of variable length thatfolds as a loop. The Sm-like proteins are thought to form a stableheteromer present in tri-snRNP particles, which are important forpre-mRNA splicing.
References
Marnef, A., et al. Int. J. Biochem. Cell Biol. 41(5):977-981(2009)Tanaka, K.J., et al. J. Biol. Chem. 281(52):40096-40106(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Yang, W.H., et al. RNA 12(4):547-554(2006)
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