CD70 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P32970 |
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Clone Names | 100525205 |
Gene ID | 970 |
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Other Names | CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CD70 |
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Synonyms | CD27L, CD27LG, TNFSF7 |
Function | Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. |
Cellular Location | Membrane; Single- pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cytokine thatbelongs to the tumor necrosis factor (TNF) ligand family. Thiscytokine is a ligand for TNFRSF27/CD27. It is a surface antigen onactivated, but not on resting, T and B lymphocytes. It inducesproliferation of costimulated T cells, enhances the generation ofcytolytic T cells, and contributes to T cell activation. Thiscytokine is also reported to play a role in regulating B-cellactivation, cytotoxic function of natural killer cells, andimmunoglobulin sythesis.
References
Arimoto-Miyamoto, K., et al. Immunology 130(1):137-149(2010)Shaw, J., et al. Blood 115(15):3051-3057(2010)Yu, S.E., et al. Mol. Cells 29(2):217-221(2010)Kozlowska, A., et al. J. Rheumatol. 37(1):53-59(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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